Updated: March 31, 2024
Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity …
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Immune 31: Immunology of COVID-19, part three Updated for 2024
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26 Comments on “Immune 31: Immunology of COVID-19, part three Updated for 2024”
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Thank you. Could you list the specific subjects discussed in each episode in this series.
Having done a lot of information security consulting and digital forensics/open source intelligence work,the immunization passport idea does have way too many serious implications on a number of issues among them private security,national security and by extension security concerns on a geopolitical level.
There are also grave socio-economic concerns(as touched upon in the podcast),and implications on civil liberties and democracy.
I have a lot of sympathy for the arguments for this solution,but I think we need to take a step back and consider what we actually are proposing here.
I don't see any reason why a vaccine won't be available within 12-18 months. The old paradigms of standard Phase 1,2,3 vaccine clinical trial are gone, since we are dealing with a GLOBAL EXISTENTIAL threat. New molecular technologies, new collaborations worldwide among research groups, computational analysis, and new regulatory climates will translate to a vaccine in 12-18 months. Where there is a political will and an outcry from the public, there will be a way.
Didn't Bill Gates come up with the immunity certificate idea first?
Absolutely Brilliant Presentation 👌
Chloroquine in Amazonian countries has been given as an "inoculation" for ppl that have to work to exposed areas. They advise to take a dose b4 exposure, then keep a dose during and after exposure. Usually is a smaller dose that the ones that are been used in covid19 treatments.
This has been for decades now and since no control has been taken, no real data has been acquired. Still no side effects has been reported so far.
These podcasts are fantastic. Thank you!
I would be very interested to hear more on the link between smoking / nicotine and decreased risk of severe disease.
I'm not sure I had it due to testing restrictions but was really sick most of March and had almost all symptoms incl loss of smell/taste. I'm in Ontario Canada about 2 hrs east of Toronto along Lake Ontario, a 9-10 hr drive from NYC and 1 hr from nearest border crossing to NY.
Mine felt like I was getting a cold then went away a couple days at end of Feb then hit me on March 5 through the 25th. The dry throat thing, absolutely. I couldn't drink enough water but it hurt to swallow too. Soup helped a lot and ginger ale. The initial dry cough became a deeper cough until on day 7 I called around and was told to come to walk-in clinic as she could tell I was struggling to breathe when talking to her with my torn up voice. Tightness in chest. I was coughing in fits a d gasping at the end similar to whooping cough but deeper. The dr had no ppe or masks required since I hadn't traveled (I worked in open office call center that shares single entrance into building with both a daycare center and a charity bingo hall so both the youngest and oldest in a perfect viral waiting to happen location). So dry eyes are the norm there and electric heat in wintertime in my apt also means I'm used to dry eyes. I do recall bringing eye drops to work that week prior. Which I don't tend to do.
I tend to get strep often (annually) for the past 15+ yrs so know it and know what day amoxicillin world for me and what it working feels like. When I went to the dr I was told I had strep tonsillitis and mild pneumonia. No swabs for anything taken. He even joked that at least it wasn't COVID-19 like I was worried it was. By this point I had been coughing so badly I had barely a voice left, whispering = coughing fits and by then my ribs hurt and throat raw as heck. Also there's this really nasty phlegm by this point it's white to pale yellow, ok nothing off too much there but omg. Sorry this is disgusting but seriously it was the hardest to get up, so gross and thick, and it just kept coming for over 2 weeks. I went through 2 standard boxes of Kleenex. Nothing like bronchitis, worse. I had childhood asthma too it's not like that or allergic resp reactions. It's like all combined, or bronchitis + whooping cough + worst hangover ever (migraine for days) + dehydration + streptococcal tonsillitis and pneumonia.
This wasn't normal strep. The amoxicillin did absolutely nothing to help. It felt like strep coming on days 1-3 but too much coughing and by day 5 I knew I was really not feeling well.
I also got flu shot mid to late November I believe. I had what was like strep but worse very end of November into December after Black Friday runned me down with 70 hrs worked in 9 days doing customer service and retail lol the dr then gave different antibiotics for a sinus throat and ear infection which was weird because I never get ear infections ever not even as a kid. I was off for 5-6 days drs orders.
When I was really sick in March by day 6-7 my two Persians who are inseparable from me we're more goobery and reply than normal, were coughing and sneezing more, and snoring louder than normal (brachycephalic Persians are really sensitive to cat colds so it's obvious when they are fighting something off). They were both fine within 3-4 days but gave me weird looks when I tried to call them for over two weeks from my torn to heck voice and throat.
I'm pretty average 34 yr old with no preexisting conditions or comorbidities except I vape and am allergic to dust and most trees lol
Monoonal antibody to help?? Maybe or drugs cocktails..
Everyone who lives here with me got sick with COVID-19. Of the four of us, I was the only one who got a flu shot. My mom and I were exposed directly with think because we were sitting next to some people (including a bunch of kids) from Wuhan on a plane, although none of them were sick. I got my flu shot at the end of September and we were on that plane in January. I had been sick with a common cold and then strep throat in mid-December, but I recovered at least a week before we were on that plane.
My mom got sick first shortly after we came home from our one-day trip, then my brother got sick shortly afterwards, although he never got all that sick being the youngest one in his mid-30s. I had really bad pink eye a few days after we got back but it went away after I flushed it with a lot of eye drops for about a week. I also had an extremely dry throat to the point that I would cough and get watery eyes unless I drank gin so I drank gin obviously. To this day, my eyes are still putting out more of what I generally call eye boogers but the redness and pain has gone away. After I thought I was well from the pink eye for a week, I got a headache that I just couldn't shake no matter what I tried and a runny nose, which I attributed to allergies like I said below. Then I had diarrhea and a fever the next day, at which point I realized that I was sick again.
The fourth person in our household right now is a friend of mine who is staying with us because he was living with a childhood buddy who died suddenly and so he was staying with us until he could find an apartment. He got sick with everything from the flu to at least one cold, if not two. He actually developed the pink eye before I did but it was only my mom and I who were on that plane with that class from Wuhan (very nice people, I might add, who probably knew nothing of the emerging pandemic since they recommended that we visit Wuhan if we ever went to China). In any case, my friend didn't realize he was sick until maybe five days after I had realized I was sick and I had insisted on staying away from everyone in the house when I got sick, plus I started cleaning the commonly touched surfaces after everyone else was in bed because I had been following the early reports out of China and was more concerned than everyone else around here about it.
We have all come through the worst of it without having to step foot in a hospital, although I can say in hindsight that I probably almost died of this but was too stubborn to go into the hospital for fear of taking up resources. The big battle seemed to be with my immune system rather than with the virus itself. My mom and I have a rare disease that causes a lot of problems with inflammation (Dercum's disease) and that's likely what made my situation quite tenuous for about three days (starting on day ten of realizing I was sick). I almost swelled up to the point that I couldn't get pee to flow out of my bladder through my ureter because of the inflammation. I realized that if I couldn't get the inflammation out by peeing it out, I would have to go to the hospital and I have been enjoying this social distancing thing so I didn't want to go to the hospital where all the people were. I basically dehydrated myself out of that crisis. The only trouble is that the swelling seems to return as soon as I stop taking ibuprofen (which I only started taking in the first place once the pain from the swelling was so bad that I literally didn't care if taking ibuprofen killed me so long as it took some of the pain away). So there's some long-term inflammation going on here because it's been two months since I first realized that I was sick. I seem to have gotten this part worse than everyone else, although everyone else reported some oddities with their kidneys for a few days.
Now maybe I got vaccinated too long before I got sick but my friend had been sick with the actual flu and still got sick with COVID-19 probably two or three weeks after he recovered from the flu. Maybe we'll be able to shed more light on this once people are exposed to COVID-19 for a second time because I really think that the body doesn't notice it for a long time when you first get it. I attribute my continued problems with inflammation to there being a lot of tissue damage from the infection and therefore a lot of clean up work to be done by my body that was already ridiculous when it comes to swelling.
I know SARS-CoV-2 was replicating in my gut because the first clue I had that I might actually be sick with something was diarrhea and horrendous abdominal pain. I attributed it to having eaten too much ice cream at first but the pain didn't go away and I spiked a fever the next day. I was probably sick for at least a week before that because I had a headache and a somewhat runny nose, but I thought that was probably allergies because the orange trees had just started to blossom and I'm really allergic to that pollen.
Great podcast guys, I wonder if there is a scientific true in the fact that a low levels of unspecific immunity proteins can play a role in the spreading of covid-19. If so global endemic ergo cholecalciferol deficit may let overall population more susceptible to the infection? I mean because of our life style and protection against uv to prevent melanoma most population got low levels of vitamin d, which in turn may lead towards a weak immune system in the highly industrialized countries. I mean it would make sense check vit d levels in Spain and Italy versus China and see if there is a relationship in infection rate and prevalence of vitamin d deficit?
Here in Catalonia we got a clinical trial going on with hydroxychloroquine lead by Dr. Oriol Mitja may be he could join you on your next pod cast! That would be nice to have a first hand of how's going on I mean reducing the infection rate seems the fastest way to control the pandemic until vaccine if ever is found.
Can the virus replicate or not at a given intercellular zinc concentration? And with ionofer chemistry is it really such a big deal achieving it? We are looking at very low mortality under 50 y.o. Yes, this is outside the immune system, but Aids is handled from a multipronged perspective. Also, isn't CODEX sensitivity 100% along with specificity too? It better be given where the stock trades. And, by the way Viet Nam borders China, and we are looking at zero impact with small rounding error, and normally, without this fluke it would have been absolutely zero impact. My Asian economist says "the West is a mess because they listened to the WHO". Why protect our friend's reputations?
What is the spelling of her name, Sydney Leifer?
Aren't there flying "treadmills" for birds? Why not do it for bats? I mean flying into a wind etc.. Wind tunnels and so on.
The diversity tribe has changed and cleansed the south of it history ,culture and sense of identity as white people ! Traditional spirituality where?
science must be objective, all prejudice should be removed to the extent human possible ! if you don't agree with the article on cd147 , btw a receptor targeted by hiv, can you at least hypothetically agree that if it turns out to do so, it will be very very significant ! I wonder if psychology, reputation and peer pressure is stoping this article from being peer reviewed quickly ? human psychology works both ways, in exajuration but also in denial ! cognitive dissonance is a bummer . there is no such think as objective pure science – it is always exogenously influenced by psychology politics and economics – to deny it is wishful thinking! also presumable this cd147 issue should be investigated with great resources immediately !!
what you miss is that from a bioethical, legal and indeed ultimately political point of view, it is entirely different for a citizen to make an informed choice to take a vaccine for their benefit than to say the benefit is for herd immunity or other people! the vax people as crazy as they might be income repescts may very well not like being misrepresented. to others and too yourselves. Also lets say a mandated vaccine harms people or their children – we could have stake burnings again politically. we have here a intersection of various fields and as it characteristic of our society and age, experts over esteem their particular area, overstreching what they can rightfully claim to know or have authority in. it is also very characteristic to be superciliously arrogant – the supercilious arrogence of science is probably a bigger threat to civilisation than terrorists. many problems have their roots in this, think economic crisis in failings of economic science! in particular I would like to see an expert in biological warfare on because I do not think the guests have any competence in that matter at all to give authoritative views.
Name and pertinent questions ONLY please…no one cares how much they like the show.
"All that probably happened long before we saw it…." unless it's Founder was Doctor Shi herself? Probably isn't a valid scientific conclusion.
Just brilliant! 👌
Love you guys. Thanks for informing us.
In the literature from before the crisis, people mentioned something they called hope.
What was hope?
A) a mineral?
B) a country? or
C) a vegetable?
Surely the gut acids intestinal acidic system would destroy the virus remnant therefore viruses are not detected in the stools.
Wow first to view this. Iam a big Fan these days. I would like you guys to also explore the covid spread in countries like india. The death numbers are absolutely true and are just 2000 out of 1.4 billion people although the comorbidities like diabetes are very very high. Can you guys take a detailed look at south asia especially India which may give some interesting insights like bcg vaccine, hot weather, or existing acquired immunity due to constant fight against various pathogens or any food or genetic factors?